Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
Identifieur interne : 002964 ( Main/Exploration ); précédent : 002963; suivant : 002965Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
Auteurs : Darren J. Creek [Australie] ; Muriel Mazet [France] ; Fiona Achcar [Royaume-Uni] ; Jana Anderson [Royaume-Uni] ; Dong-Hyun Kim [Royaume-Uni] ; Ruwida Kamour [Libye] ; Pauline Morand [France] ; Yoann Millerioux [France] ; Marc Biran [France] ; Eduard J. Kerkhoven [Suède] ; Achuthanunni Chokkathukalam [Royaume-Uni] ; Stefan K. Weidt [Royaume-Uni] ; Karl E. V. Burgess [Royaume-Uni] ; Rainer Breitling [Royaume-Uni] ; David G. Watson [Royaume-Uni] ; Frédéric Bringaud [France] ; Michael P. Barrett [Royaume-Uni]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Acide succinique, Glucose, Glycérol, Trypanosoma brucei brucei.
- physiologie : Voie des pentoses phosphates, Voies et réseaux métaboliques.
- Animaux, Cellules cultivées, Métabolomique, Oxydoréduction.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glucose, Glycerol, Succinic Acid.
- metabolism : Trypanosoma brucei brucei.
- methods : Metabolomics.
- physiology : Metabolic Networks and Pathways, Pentose Phosphate Pathway.
- Animals, Cells, Cultured, Oxidation-Reduction.
Abstract
Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of
Url:
DOI: 10.1371/journal.ppat.1004689
PubMed: 25775470
PubMed Central: 4361558
Affiliations:
- Australie, France, Libye, Royaume-Uni, Suède
- Angleterre, Aquitaine, Grand Manchester, Nottinghamshire, Nouvelle-Aquitaine, Écosse
- Bordeaux, Glasgow, Manchester, Nottingham
- Université de Bordeaux, Université de Glasgow, Université de Manchester, Université de Nottingham
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Le document en format XML
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Burgess</name><affiliation wicri:level="4"><nlm:aff id="aff008"><addr-line>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Breitling, Rainer" sort="Breitling, Rainer" uniqKey="Breitling R" first="Rainer" last="Breitling">Rainer Breitling</name><affiliation wicri:level="4"><nlm:aff id="aff009"><addr-line>Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Watson, David G" sort="Watson, David G" uniqKey="Watson D" first="David G." last="Watson">David G. Watson</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Bringaud, Frederic" sort="Bringaud, Frederic" uniqKey="Bringaud F" first="Frédéric" last="Bringaud">Frédéric Bringaud</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. 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Creek</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Parkville, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Mazet, Muriel" sort="Mazet, Muriel" uniqKey="Mazet M" first="Muriel" last="Mazet">Muriel Mazet</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Achcar, Fiona" sort="Achcar, Fiona" uniqKey="Achcar F" first="Fiona" last="Achcar">Fiona Achcar</name><affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Wellcome Trust Centre of Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre of Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Anderson, Jana" sort="Anderson, Jana" uniqKey="Anderson J" first="Jana" last="Anderson">Jana Anderson</name><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Department of Public Health, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kim, Dong Hyun" sort="Kim, Dong Hyun" uniqKey="Kim D" first="Dong-Hyun" last="Kim">Dong-Hyun Kim</name><affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, University Park, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Kamour, Ruwida" sort="Kamour, Ruwida" uniqKey="Kamour R" first="Ruwida" last="Kamour">Ruwida Kamour</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya</addr-line></nlm:aff><country xml:lang="fr">Libye</country><wicri:regionArea>Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli</wicri:regionArea><wicri:noRegion>Tripoli</wicri:noRegion></affiliation></author><author><name sortKey="Morand, Pauline" sort="Morand, Pauline" uniqKey="Morand P" first="Pauline" last="Morand">Pauline Morand</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Millerioux, Yoann" sort="Millerioux, Yoann" uniqKey="Millerioux Y" first="Yoann" last="Millerioux">Yoann Millerioux</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Biran, Marc" sort="Biran, Marc" uniqKey="Biran M" first="Marc" last="Biran">Marc Biran</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Kerkhoven, Eduard J" sort="Kerkhoven, Eduard J" uniqKey="Kerkhoven E" first="Eduard J." last="Kerkhoven">Eduard J. Kerkhoven</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Systems and Synthetic Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Systems and Synthetic Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg</wicri:regionArea><wicri:noRegion>Göteborg</wicri:noRegion></affiliation></author><author><name sortKey="Chokkathukalam, Achuthanunni" sort="Chokkathukalam, Achuthanunni" uniqKey="Chokkathukalam A" first="Achuthanunni" last="Chokkathukalam">Achuthanunni Chokkathukalam</name><affiliation wicri:level="4"><nlm:aff id="aff008"><addr-line>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Weidt, Stefan K" sort="Weidt, Stefan K" uniqKey="Weidt S" first="Stefan K." last="Weidt">Stefan K. Weidt</name><affiliation wicri:level="4"><nlm:aff id="aff008"><addr-line>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Burgess, Karl E V" sort="Burgess, Karl E V" uniqKey="Burgess K" first="Karl E. V." last="Burgess">Karl E. V. Burgess</name><affiliation wicri:level="4"><nlm:aff id="aff008"><addr-line>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Breitling, Rainer" sort="Breitling, Rainer" uniqKey="Breitling R" first="Rainer" last="Breitling">Rainer Breitling</name><affiliation wicri:level="4"><nlm:aff id="aff009"><addr-line>Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Watson, David G" sort="Watson, David G" uniqKey="Watson D" first="David G." last="Watson">David G. Watson</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Bringaud, Frederic" sort="Bringaud, Frederic" uniqKey="Bringaud F" first="Frédéric" last="Bringaud">Frédéric Bringaud</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Résonance Magnétique des Systèmes Biologiques, Université de Bordeaux, CNRS UMR-5536, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. Barrett</name><affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Wellcome Trust Centre of Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre of Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff008"><addr-line>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Glucose (metabolism)</term><term>Glycerol (metabolism)</term><term>Metabolic Networks and Pathways (physiology)</term><term>Metabolomics (methods)</term><term>Oxidation-Reduction</term><term>Pentose Phosphate Pathway (physiology)</term><term>Succinic Acid (metabolism)</term><term>Trypanosoma brucei brucei (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide succinique (métabolisme)</term><term>Animaux</term><term>Cellules cultivées</term><term>Glucose (métabolisme)</term><term>Glycérol (métabolisme)</term><term>Métabolomique ()</term><term>Oxydoréduction</term><term>Trypanosoma brucei brucei (métabolisme)</term><term>Voie des pentoses phosphates (physiologie)</term><term>Voies et réseaux métaboliques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term><term>Glycerol</term><term>Succinic Acid</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Trypanosoma brucei brucei</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Metabolomics</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide succinique</term><term>Glucose</term><term>Glycérol</term><term>Trypanosoma brucei brucei</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Voie des pentoses phosphates</term><term>Voies et réseaux métaboliques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Metabolic Networks and Pathways</term><term>Pentose Phosphate Pathway</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Oxidation-Reduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Métabolomique</term><term>Oxydoréduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of <italic>Trypanosoma brucei</italic>, a parasite responsible for human African trypanosomiasis. Glucose enters many branches of metabolism beyond glycolysis, which has been widely held to be the sole route of glucose metabolism. Whilst pyruvate is the major end-product of glucose catabolism, its transamination product, alanine, is also produced in significant quantities. The oxidative branch of the pentose phosphate pathway is operative, although the non-oxidative branch is not. Ribose 5-phosphate generated through this pathway distributes widely into nucleotide synthesis and other branches of metabolism. Acetate, derived from glucose, is found associated with a range of acetylated amino acids and, to a lesser extent, fatty acids; while labelled glycerol is found in many glycerophospholipids. Glucose also enters inositol and several sugar nucleotides that serve as precursors to macromolecule biosynthesis. Although a Krebs cycle is not operative, malate, fumarate and succinate, primarily labelled in three carbons, were present, indicating an origin from phosphoenolpyruvate via oxaloacetate. Interestingly, the enzyme responsible for conversion of phosphoenolpyruvate to oxaloacetate, phosphoenolpyruvate carboxykinase, was shown to be essential to the bloodstream form trypanosomes, as demonstrated by the lethal phenotype induced by RNAi-mediated downregulation of its expression. 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Barrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Creek, Dj" uniqKey="Creek D">DJ Creek</name></author><author><name sortKey="Jankevics, A" uniqKey="Jankevics A">A Jankevics</name></author><author><name sortKey="Breitling, R" uniqKey="Breitling R">R Breitling</name></author><author><name sortKey="Watson, Dg" uniqKey="Watson D">DG Watson</name></author><author><name sortKey="Barrett, Mp" uniqKey="Barrett M">MP Barrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akoka, S" uniqKey="Akoka S">S Akoka</name></author><author><name sortKey="Barantin, L" uniqKey="Barantin L">L Barantin</name></author><author><name sortKey="Trierweiler, M" uniqKey="Trierweiler M">M Trierweiler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harlow, E" uniqKey="Harlow E">E Harlow</name></author><author><name sortKey="Lane, D" uniqKey="Lane D">D Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sambrook, J" uniqKey="Sambrook J">J Sambrook</name></author><author><name sortKey="Fritsch, Ef" uniqKey="Fritsch E">EF Fritsch</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T Maniatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denise, H" uniqKey="Denise H">H Denise</name></author><author><name sortKey="Giroud, C" uniqKey="Giroud C">C Giroud</name></author><author><name sortKey="Barrett, Mp" uniqKey="Barrett M">MP Barrett</name></author><author><name sortKey="Baltz, T" uniqKey="Baltz T">T Baltz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bringaud, F" uniqKey="Bringaud F">F Bringaud</name></author><author><name sortKey="Peyruchaud, S" uniqKey="Peyruchaud S">S Peyruchaud</name></author><author><name sortKey="Baltz, D" uniqKey="Baltz D">D Baltz</name></author><author><name sortKey="Giroud, C" uniqKey="Giroud C">C Giroud</name></author><author><name sortKey="Simpson, L" uniqKey="Simpson L">L Simpson</name></author><author><name sortKey="Baltz, T" uniqKey="Baltz T">T Baltz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Libye</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Grand Manchester</li><li>Nottinghamshire</li><li>Nouvelle-Aquitaine</li><li>Écosse</li></region><settlement><li>Bordeaux</li><li>Glasgow</li><li>Manchester</li><li>Nottingham</li></settlement><orgName><li>Université de Bordeaux</li><li>Université de Glasgow</li><li>Université de Manchester</li><li>Université de Nottingham</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Creek, Darren J" sort="Creek, Darren J" uniqKey="Creek D" first="Darren J." last="Creek">Darren J. Creek</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Mazet, Muriel" sort="Mazet, Muriel" uniqKey="Mazet M" first="Muriel" last="Mazet">Muriel Mazet</name></region><name sortKey="Biran, Marc" sort="Biran, Marc" uniqKey="Biran M" first="Marc" last="Biran">Marc Biran</name><name sortKey="Bringaud, Frederic" sort="Bringaud, Frederic" uniqKey="Bringaud F" first="Frédéric" last="Bringaud">Frédéric Bringaud</name><name sortKey="Millerioux, Yoann" sort="Millerioux, Yoann" uniqKey="Millerioux Y" first="Yoann" last="Millerioux">Yoann Millerioux</name><name sortKey="Morand, Pauline" sort="Morand, Pauline" uniqKey="Morand P" first="Pauline" last="Morand">Pauline Morand</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Achcar, Fiona" sort="Achcar, Fiona" uniqKey="Achcar F" first="Fiona" last="Achcar">Fiona Achcar</name></region><name sortKey="Anderson, Jana" sort="Anderson, Jana" uniqKey="Anderson J" first="Jana" last="Anderson">Jana Anderson</name><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. Barrett</name><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. Barrett</name><name sortKey="Breitling, Rainer" sort="Breitling, Rainer" uniqKey="Breitling R" first="Rainer" last="Breitling">Rainer Breitling</name><name sortKey="Burgess, Karl E V" sort="Burgess, Karl E V" uniqKey="Burgess K" first="Karl E. V." last="Burgess">Karl E. V. Burgess</name><name sortKey="Chokkathukalam, Achuthanunni" sort="Chokkathukalam, Achuthanunni" uniqKey="Chokkathukalam A" first="Achuthanunni" last="Chokkathukalam">Achuthanunni Chokkathukalam</name><name sortKey="Kim, Dong Hyun" sort="Kim, Dong Hyun" uniqKey="Kim D" first="Dong-Hyun" last="Kim">Dong-Hyun Kim</name><name sortKey="Watson, David G" sort="Watson, David G" uniqKey="Watson D" first="David G." last="Watson">David G. Watson</name><name sortKey="Weidt, Stefan K" sort="Weidt, Stefan K" uniqKey="Weidt S" first="Stefan K." last="Weidt">Stefan K. Weidt</name></country><country name="Libye"><noRegion><name sortKey="Kamour, Ruwida" sort="Kamour, Ruwida" uniqKey="Kamour R" first="Ruwida" last="Kamour">Ruwida Kamour</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Kerkhoven, Eduard J" sort="Kerkhoven, Eduard J" uniqKey="Kerkhoven E" first="Eduard J." last="Kerkhoven">Eduard J. Kerkhoven</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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